Fig. 1

Differential expression of interferon and its stimulated genes in macrophages after M. tuberculosis infection; A Schematic of infection of M. tuberculosis in different macrophages; B–C Reactome pathway enrichment analysis of differential expression genes (DEGs) in the macrophages; D The cnet plot was generated for interferon and its stimulated genes; E Gene expression profile of IFNs and ISGs in the THP-1 cells by RNA-Seq; F Gene expression profile of IFNs and ISGs in the Raw264.7 cells by RNA-Seq; G–H RNA-Seq data were validated by qRT-PCR in human and murine macrophages respectively. Data presented by mean ± SEM. All experiments were performed in triplicate. The values of *p < 0.05 were considered a statistically significant difference