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Fig. 6 | Animal Diseases

Fig. 6

From: Investigation of the epidemiology, pathogenicity and immunogenicity of Bordetella bronchiseptica isolated from cats and dogs in China from 2021 to 2023

Fig. 6

Investigation of the immunogenicity of the Bb WH1218 strain in cats. A Experimental strategy. B The levels of Bb-specific IgG antibodies against the Bb WH1218 strain in cats were measured at different time points (days 0, 7, 14, 21, 28 and 35) following the first immunization with three different doses of WH1218. C Clinical scores of cats immunized with three different doses of the WH1218 strain measured after the WH1218 challenge. D Protection curve of WH1218-challenged cats immunized with three different doses of the WH1218 strain. E Cats were immunized with three different doses of WH1218, and the amount of Bb in the lungs was determined 14 days after the WH1218 challenge. F Pathological lesions in the lungs of cats in different immunization dose groups at 14 days after challenge. Pathological lesions are indicated with arrows. Ns, not significant; *, p < 0.05; **, p < 0.01; ** *, p < 0.001 and ****, and p < 0.0001

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