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Fig. 8 | Animal Diseases

Fig. 8

From: Taurodeoxycholic acid alleviates diquat-induced intestinal barrier function injury in mice through the upregulation of Nrf2-mediated signaling pathway

Fig. 8

TDCA alleviates diquat-induced oxidative stress and barrier injury in intestinal epithelial cells through the Nrf2 pathway in vitro. A Experimental grouping scheme. B-F MDA, SOD, GSH-Px, CAT, and T-AOC contents of MODE-K cells in each group. G ZO-1 protein and Occludin protein expression was analyzed by western blot in the CON group, DQ + TDCA group and DQ + TDCA + ML385 group. H-I ZO-1 and Occludin protein expression in each group. n = 3 for B-I. All the data are presented as the means ± SEMs. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 indicate between-group comparisons. CON, control; DQ, diquat; TDCA, taurodeoxycholic acid; MDA, malondialdehyde; SOD, superoxide dismutase; GSH-Px, glutathione peroxidase; CAT, catalase; T-AOC, total antioxidant capacity; ML385, specific Nrf2 inhibitor; TDCA (50) indicates treatment with 50 μM TDCA

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Animal Diseases

ISSN: 2731-0442