Table 4 Targeting peptides
From: Functional immunopeptides: advancing prevention and therapeutic strategies against animal diseases
Type | Sequence | Target receptor | Pathogen | Outcome | Source |
|---|---|---|---|---|---|
DC-targeting peptide | FYPSYHSTPQRP | TLR4 CD80 MHC-II | H9 N2 Avian Influenza | - Activate DCs - Enhance adaptive immune response - Facilitate T and B-cell activation | |
Transmissible gastroenteritis coronavirus (TGEV) | - Enhance antigen presentation - Stimulate T and B-cell activation | (Jin et al. 2018) | |||
Newcastle disease virus | - Increase IgA - Stimulate T-cell activation | (Y. Jiang et al. 2015) | |||
Macrophage-targeting peptide | SRCR 5–9 | CD163 | PRRSV | Inhibit PRRSV infection by blocking virus attachment to CD163 receptor | |
4H7 8H2 | Inhibit PRRSV infection by blocking virus attachment and replication postattachment to CD163 receptor | ||||
DC-targeting peptide | NiV G (ECD) NiV F (aa 45–90) NiV N (aa 318–355) | CD40 | Nipah virus | - Induce protective immunity and cross-neutralization against different strains - Enhance T and B-cell responses | (Pastor et al. 2024) |
DC-targeting peptides | SPHLHTSSPWER | Not specified | IBDV | Enhances binding to DCs | (S. Ma et al. 2019) |
DC-targeting peptides | LYPPPY (CTLA4-6 aa) | B7 | PEDV | - Enhance antigen capture - T-cell activation | (Xia et al. 2022) |
Macrophage-targeting peptide | Chicken heterophil CATH2 (1–13)-TP5 (CbTP) RFGRFLRKIRRFRRKDVY | TLR2 | Immunosuppressive disease | Inhibit immunosuppression | (X. Wei et al. 2021) |
DC-targeting peptide | HSLRHDYGYPGH KCCYPN MYPPPY | CD86 MHC-II | Rabbit hemorrhagic disease virus (RHDV) | - Enhance antigen capture - Promote DC maturation - Increase cytokine secretion | (Xia et al. 2024) |